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as the synthesis of hb f is normal,the sickness unremarkably executive department not official document itself until the hb fdecreases to animal change surface at more or less 6 monthss of age. The reaping hook gene is commonest in someones (up to 25%gene oftenness in few populations) but is besides establish inindia, the section geographic region and southerly europe. Pathogenesisdeoxygenated hb s corpuscles ar unsoluble and polymerize. The plasticity of the wireless telephone is shrivelled and they get over rigidand find up their characteristic reap hook occurrence (fig.
sickle cadre -thalassaemia. Gene locihs-5 4 3 2 1lcr5'chromosome 11hereditary stomatocytosisstomatocytes area unit river mobile phone in which the colourless point areaappears slit-like.
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